Description

6-Chloro-5-Fluoro-2-(Trifluoromethyl)-1H-Benzimidazole is a high-value, multi-halogenated benzimidazole derivative that serves as a critical advanced pharmaceutical intermediate. Its molecular structure, featuring chloro, fluoro, and trifluoromethyl substituents, is engineered to impart specific biological activity and metabolic stability in final drug molecules. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the benzimidazole core and halogen atoms contribute to efficacy.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential use in the development of specialty chemicals and functional materials, such as ligands for catalysts or organic electronic components.

Basic Information

Product Name	6-Chloro-5-Fluoro-2-(Trifluoromethyl)-1H-Benzimidazole
CAS No.	89426-96-0
Molecular Formula	C8H3ClF4N2
Molecular Weight	238.57 g/mol
Synonyms	6-Chloro-5-fluoro-2-(trifluoromethyl)-1H-benzimidazole; 1H-Benzimidazole, 6-chloro-5-fluoro-2-(trifluoromethyl)-; 89426-96-0; 6-Chloro-5-fluoro-2-trifluoromethylbenzimidazole; 2-(Trifluoromethyl)-6-chloro-5-fluorobenzimidazole; CF3-BIM-Cl-F; 5-Fluoro-6-chloro-2-(trifluoromethyl)benzimidazole
EINECS	Contact for details

Quality Control

Our production of 6-Chloro-5-Fluoro-2-(Trifluoromethyl)-1H-Benzimidazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR, MS). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.