Description

4-Methoxybenzyl-2,2,2-Trichloroacetimidate is a versatile and highly reactive chemical building block primarily used as an imidate ester in organic synthesis. Its core value lies in its ability to act as a protective group for alcohols and as a glycosyl donor in carbohydrate chemistry, facilitating the synthesis of complex molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for advanced synthetic routes.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly in nucleoside and carbohydrate-based drug development.
• Glycosylation Reactions: Serves as a powerful glycosyl donor for the stereoselective construction of glycosidic bonds in oligosaccharide and glycoconjugate synthesis.
• Protecting Group Chemistry: Used as a 4-methoxybenzyl (PMB) protecting group for alcohols, offering orthogonal deprotection strategies in multi-step synthesis.
• Agrochemical Synthesis: Employed in the production of advanced crop protection agents and herbicides that require specific chiral intermediates.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, fragrances, and advanced materials.
• Academic & Industrial R&D: A critical tool for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	4-Methoxybenzyl-2,2,2-Trichloroacetimidate
CAS No.	89238-99-3
Molecular Formula	C10H10Cl3NO2
Molecular Weight	282.55 g/mol
Synonyms	4-Methoxybenzyl Trichloroacetimidate; p-Methoxybenzyl 2,2,2-Trichloroacetimidate; PMB-TCA; Trichloroacetimidic Acid 4-Methoxybenzyl Ester; (4-Methoxyphenyl)methyl 2,2,2-Trichloroethanimidate; 4-Methoxybenzyl Trichloroethanimidate; Glycosyl Donor PMB-TCA; p-Methoxybenzyl Trichloroacetimidate
EINECS	Contact for details

Quality Control

Our 4-Methoxybenzyl-2,2,2-Trichloroacetimidate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.