Description

5-Chloro-4-Nitrothiophene-2-Carboxylic Acid is a high-value heterocyclic building block characterized by its reactive nitro and carboxylic acid functional groups on a chlorinated thiophene core. This compound matters as a critical synthetic intermediate for the development of advanced materials and active pharmaceutical ingredients (APIs), offering precise molecular control for downstream derivatization. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting infectious diseases or acting as enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging its bioactive thiophene scaffold.
• Material Science Research: Acts as a monomer or functionalizing agent for creating conductive polymers, organic semiconductors, and advanced polymeric materials.
• Dye and Pigment Manufacturing: Employed in the production of specialized dyes and pigments due to the chromophoric nature of the nitro-thiophene system.
• Organic Synthesis Building Block: Provides a versatile platform for Suzuki coupling, amidation, esterification, and reduction reactions to create diverse chemical libraries.
• Ligand and Catalyst Development: Useful for synthesizing novel chelating ligands or organocatalysts for asymmetric synthesis and metal complexation.

Basic Information

Product Name	5-Chloro-4-Nitrothiophene-2-Carboxylic Acid
CAS No.	89166-85-8
Molecular Formula	C5H2ClNO4S
Molecular Weight	207.59 g/mol
Synonyms	4-Nitro-5-chlorothiophene-2-carboxylic acid; 5-Chloro-4-nitro-2-thiophenecarboxylic acid; 2-Thiophenecarboxylic acid, 5-chloro-4-nitro-; 5-Chloro-4-nitrothiophene-2-carboxylate; 89166-85-8; 5-Chloro-4-nitrothiophene-2-carboxylic acid; 4-Nitro-5-chloro-2-thiophenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Nitrothiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.