Description

Hexa(Ethylene Glycol) Dithiol is a high-purity, bifunctional organic compound featuring a hydrophilic hexaethylene glycol spacer terminated by two reactive thiol (-SH) groups. This molecular architecture makes it a critical heterobifunctional crosslinker and spacer arm for bioconjugation, enabling the stable attachment of biomolecules, nanoparticles, and polymers under controlled conditions. It is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors who require precise and reliable conjugation chemistry to develop novel therapeutics, biosensors, and functionalized surfaces.

Application

• Bioconjugation and Protein Modification: Acts as a heterobifunctional crosslinker for coupling proteins, peptides, or antibodies to surfaces, particles, or other biomolecules via thiol-maleimide or thiol-click chemistry.
• Surface Functionalization for Biosensors: Used to create self-assembled monolayers (SAMs) on gold or other metal surfaces, providing a hydrophilic, bio-compatible spacer layer for immobilizing probe molecules in diagnostic assays.
• Polymer and Hydrogel Synthesis: Serves as a chain extender or crosslinking agent in the synthesis of degradable, thiol-responsive polymers, hydrogels, and drug delivery systems.
• Nanoparticle Capping and Stabilization: Employed to functionalize quantum dots, gold nanoparticles, and other nanomaterials, imparting water solubility and providing reactive handles for further biolabeling.
• Micropatterning and Microarray Technology: Facilitates the precise patterning of biomolecules on chips and slides for high-throughput screening and genomic/proteomic research.
• Liposome and Drug Carrier Modification: Used to attach targeting ligands or PEG chains to liposomal surfaces, enhancing circulation time and target specificity in drug delivery applications.

Basic Information

Product Name	Hexa(Ethylene Glycol) Dithiol
CAS No.	89141-22-0
Molecular Formula	C12H26O6S2
Molecular Weight	330.46 g/mol
Synonyms	2,2'-(Ethylenedioxy)diethanethiol (dimer); 3,6,9,12,15,18-Hexaoxahenicosane-1,21-dithiol; α,ω-Dimercapto-hexa(ethylene glycol); Hexaethylene glycol dithiol; HEG-Dithiol; Dithiol-PEG6; HS-PEG6-SH; 1,21-Dimercapto-3,6,9,12,15,18-hexaoxahenicosane
EINECS	Contact for details

Quality Control

Our Hexa(Ethylene Glycol) Dithiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and titration for thiol content, to ensure it meets the high standards required for sensitive research and production applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and moisture absorption. Allow the container to reach room temperature before opening to prevent condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Thiol Titration)	≥ 90.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.