Description

(2S,3Ar,7As)-(2-α-,3A-α-,7A-Alpha)-2,3,3A,4,5,7A-Hexahydro-1H-Indole-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and complex polycyclic structure. This compound is critical for the synthesis of complex molecules, offering a precise chiral building block for research and development in medicinal chemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a building block for constructing novel molecular libraries and exploring structure-activity relationships (SAR) in drug discovery.
• Asymmetric Synthesis: Serves as a precursor or template in catalytic asymmetric reactions to introduce specific stereocenters.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Used as an analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Academic & Institutional Research: A valuable compound for studies in organic synthesis, heterocyclic chemistry, and pharmacology within university and institutional settings.

Basic Information

Product Name	(2S,3Ar,7As)-(2-α-,3A-α-,7A-Alpha)-2,3,3A,4,5,7A-Hexahydro-1H-Indole-2-Carboxylic Acid
CAS No.	89105-40-8
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	(2S,3aR,7aS)-Octahydro-1H-indole-2-carboxylic acid; (2S,3aR,7aS)-2,3,3a,4,5,7a-Hexahydro-1H-indole-2-carboxylic acid; (2S,3aR,7aS)-Hexahydro-1H-indole-2-carboxylic acid; (2S,3aR,7aS)-2-Carboxyhexahydroindole; cis-Hexahydro-1H-indole-2-carboxylic acid (stereospecific); (2S,3aR,7aS)-Perhydroindole-2-carboxylic acid; L-2,3,3a,4,5,7a-Hexahydroindole-2-carboxylic acid; (2S,3aR,7aS)-1,2,3,3a,4,5,7,7a-Octahydroindole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (2S,3Ar,7As)-(2-α-,3A-α-,7A-Alpha)-2,3,3A,4,5,7A-Hexahydro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is compatible with strong acid/organic solvent environments but should be handled accordingly. Keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.