Description

(4R,5R)-2-Chloro-4,5-Dimethyl-1,3,2-Dioxaphospholane 2-Oxide is a high-purity chiral organophosphorus compound, serving as a critical intermediate in advanced synthetic chemistry. Its value lies in its role as a versatile building block for constructing complex molecules with precise stereochemistry, enabling the development of novel pharmaceuticals and specialty materials. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality chiral synthons.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and antiviral therapies.
• Ligand Synthesis: Used in the preparation of chiral phosphine and phosphite ligands for asymmetric catalysis, enhancing reaction selectivity and yield.
• Nucleotide Chemistry: Acts as a protected phosphoramidite analog in the synthesis of modified oligonucleotides for therapeutic and diagnostic applications.
• Polymer Science: Employed as a monomer or co-monomer for creating polymers with specific stereoregularity and functional properties.
• Agrochemical Research: Serves as a building block for developing novel chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Chemical Biology Probes: Utilized to synthesize labeled compounds and probes for studying enzyme mechanisms and biomolecular interactions.

Basic Information

Product Name	(4R,5R)-2-Chloro-4,5-Dimethyl-1,3,2-Dioxaphospholane 2-Oxide
CAS No.	89104-48-3
Molecular Formula	C4H8ClO3P
Molecular Weight	170.53 g/mol
Synonyms	2-Chloro-4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide; (4R,5R)-(-)-2-Chloro-4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide; (R,R)-2-Chloro-4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide; Chloromethyl ethylene phosphate (stereospecific); Dioxaphospholane oxide derivative; Chiral cyclic chlorophosphite ester; P-Chloro-2,3-O-isopropylidene-glycerol cyclic phosphate
EINECS	Contact for details

Quality Control

Our (4R,5R)-2-Chloro-4,5-Dimethyl-1,3,2-Dioxaphospholane 2-Oxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and custom synthesis and purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.