Description

1,4-Butane-2,2,3,3-D4-Diamine 2Hcl is a deuterium-labeled derivative of 1,4-butanediamine, a valuable building block for research and development. This compound is essential for creating isotopically labeled molecules, enabling advanced studies in pharmacokinetics, metabolic pathways, and reaction mechanisms. It is primarily utilized by pharmaceutical researchers, analytical chemists, and material scientists working in drug discovery, proteomics, and NMR spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of 1,4-butanediamine and related compounds in complex matrices.
• Metabolic Pathway Tracing: Serves as a deuterium-labeled tracer in metabolic studies to investigate the biological fate and transformation of polyamine compounds.
• Pharmaceutical Research & Development: A key precursor for synthesizing deuterated drug candidates to improve metabolic stability and for conducting Absorption, Distribution, Metabolism, and Excretion (ADME) studies.
• NMR Spectroscopy Solvent & Reagent: Employed as a specialty reagent or shift agent in nuclear magnetic resonance spectroscopy due to its deuterium atoms.
• Biochemical Research: Used in proteomics and enzymology research to study enzyme mechanisms involving polyamines.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of novel polymers and materials where isotopic labeling is required for analysis.

Basic Information

Product Name	1,4-Butane-2,2,3,3-D4-Diamine 2Hcl
CAS No.	88972-24-1
Molecular Formula	C4H8D4N2·2HCl
Molecular Weight	179.10 g/mol
Synonyms	1,4-Butanediamine-2,2,3,3-d4 dihydrochloride; Tetradeutero-1,4-butanediamine dihydrochloride; 1,4-Diaminobutane-2,2,3,3-d4 2HCl; Putrescine-2,2,3,3-d4 dihydrochloride; Butane-1,4-diamine-2,2,3,3-d4 dihydrochloride; Deuterated Putrescine Dihydrochloride; 1,4-BD-d4 2HCl; 1,4-Butylenediamine-d4 dihydrochloride
EINECS	Contact for details

Quality Control

Our 1,4-Butane-2,2,3,3-D4-Diamine 2Hcl is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to ensure high isotopic purity and chemical identity. Certificates of Analysis (COA) detailing batch-specific results for isotopic enrichment, chemical purity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.