Description

(R)-Methyl 2-Amino-3-Mercaptopropanoate CAS NO 88806-98-8 is a high-purity, chiral amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the unique combination of a protected amino group and a reactive thiol functionality, enabling precise stereochemical control in complex molecule assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of ACE inhibitors, renin inhibitors, and other cardiovascular drugs.
• Peptide Synthesis: Building block for introducing cysteine analogs or creating disulfide bridges in custom peptides and peptidomimetics.
• Asymmetric Catalysis: Ligand precursor for chiral catalysts used in enantioselective transformations.
• Bioconjugation Chemistry: Utilized for site-specific labeling of proteins, antibodies, and other biomolecules via thiol-reactive chemistry.
• Protease Inhibitor Development: Core structure in the research and development of cysteine protease inhibitors.
• Chemical Biology Probes: Used to create activity-based probes for studying enzyme function and mechanism.

Basic Information

Product Name	(R)-Methyl 2-Amino-3-Mercaptopropanoate
CAS No.	88806-98-8
Molecular Formula	C4H9NO2S
Molecular Weight	135.18 g/mol
Synonyms	D-Cysteine Methyl Ester; (R)-Cysteine Methyl Ester; Methyl (R)-2-Amino-3-mercaptopropanoate; (R)-Methyl Cysteinate; L-Cysteine methyl ester (enantiomer); Methyl D-cysteinate; (2R)-2-Amino-3-sulfanylpropanoic acid methyl ester; H-D-Cys-OMe
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-Amino-3-Mercaptopropanoate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation of the thiol group. The container should be kept in a cool, dry, and well-ventilated area, separate from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.