Description

5-Iodo-Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. This compound is particularly valued for its reactive iodine substituent and ester functionality, which enable precise molecular construction in complex chemical environments. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents and herbicides, leveraging its unique thiophene scaffold.
• Material Science Precursor: Serves as a building block for creating functionalized polymers, organic semiconductors, and conductive materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex biaryl structures.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems and mechanisms.

Basic Information

Product Name	5-Iodo-Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	88770-20-1
Molecular Formula	C7H5IO2S
Molecular Weight	280.08 g/mol
Synonyms	Methyl 5-Iodothiophene-3-carboxylate; 3-Thiophenecarboxylic acid, 5-iodo-, methyl ester; 5-Iodo-3-thiophenecarboxylic acid methyl ester; Methyl 5-iodo-3-thiophenecarboxylate; 5-Iodothiophene-3-carboxylic acid methyl ester; 88770-20-1; Methyl 5-iodothiophene-3-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Iodo-Thiophene-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.