Description

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate is a specialized organophosphorus compound featuring a phosphonate ester core flanked by trifluoroethoxy and methoxycarbonylmethyl groups. This unique structure makes it a valuable reagent in advanced organic synthesis, particularly for the introduction of fluorinated and activated methylene components. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules where precise control over stereochemistry and electronic properties is critical.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Horner-Wadsworth-Emmons (HWE) Reagent: Serves as a specialized phosphonate reagent in olefination reactions to generate α,β-unsaturated esters with high stereoselectivity (E/Z control).
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoroethyl groups can impart favorable lipophilicity and biological activity.
• Material Science Precursor: Employed in the development of specialty polymers and functional materials that benefit from incorporated phosphorus and fluorine atoms.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing novel phosphonate-based ligands for metal catalysis.
• Academic & Industrial R&D: A versatile tool for methodological development in organic chemistry, enabling new routes to complex, fluorinated organic molecules.

Basic Information

Product Name	Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate
CAS No.	88738-78-7
Molecular Formula	C9H11F6O5P
Molecular Weight	344.15 g/mol
Synonyms	(Methoxycarbonylmethyl)phosphonic Acid Bis(2,2,2-trifluoroethyl) Ester; Diethyl (Methoxycarbonylmethyl)phosphonate, Trifluoroethyl Analog; Phosphonoacetic Acid Trimethyl Ester, Bis(2,2,2-trifluoroethyl) Ester; (Carbomethoxymethyl)phosphonic Acid Bis(2,2,2-trifluoroethyl) Ester; Bis(trifluoroethyl) (Methoxycarbonylmethyl)phosphonate; TFEP Reagent
EINECS	Contact for details

Quality Control

Our Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards demanded by pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.