Description

1-Benzyl-Piperidine-3,3,5,5-D4-4-Ol CAS NO 88227-11-6 is a deuterated derivative of 1-benzyl-4-piperidinol, featuring four deuterium atoms at the 3,3,5,5 positions. This deuteration is critical for enhancing metabolic stability and providing a non-radioactive isotopic label, making it an invaluable tool in advanced research and development. It is primarily utilized by pharmaceutical and agrochemical scientists for applications in drug discovery, metabolic pathway studies, and as a stable internal standard in quantitative mass spectrometry.

Application

• Pharmaceutical Research & Drug Discovery: Used as a deuterated building block or intermediate in the synthesis of novel active pharmaceutical ingredients (APIs) to study isotope effects on metabolism, pharmacokinetics, and bioavailability.
• Metabolic Studies & Tracing: Serves as a stable, non-radioactive isotopic tracer in mass spectrometry-based assays to investigate biochemical pathways and metabolite identification.
• Analytical Reference Standard: Employed as a high-purity internal standard in LC-MS and GC-MS quantitative analysis to ensure accuracy and reliability in method development and validation.
• Agrochemical Development: Acts as a key intermediate in the synthesis of deuterated agrochemicals, where the deuterium label can improve environmental persistence and efficacy.
• Material Science Research: Investigated for potential use in the development of advanced organic electronic materials and liquid crystals due to its modified piperidine structure.

Basic Information

Product Name	1-Benzyl-Piperidine-3,3,5,5-D4-4-Ol
CAS No.	88227-11-6
Molecular Formula	C12H13D4NO
Molecular Weight	195.29 g/mol
Synonyms	1-Benzyl-4-hydroxy-3,3,5,5-tetradeuteropiperidine; 1-Benzyl-4-piperidinol-3,3,5,5-d4; 4-Piperidinol, 1-(phenylmethyl)-, 3,3,5,5-tetradeuterio-; 1-Benzyl-4-hydroxypiperidine-d4; 1-Benzylpiperidin-4-ol-d4; 1-(Phenylmethyl)-3,3,5,5-tetradeuterio-4-piperidinol; BPP-d4
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems. Each batch of 1-Benzyl-Piperidine-3,3,5,5-D4-4-Ol undergoes rigorous analytical testing, including NMR (¹H, ²H, ¹³C), HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (deuterium enrichment ≥98 atom % D), and chemical purity (typically ≥95%). Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (²H NMR)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.