Description

3',5'-o-[Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]-Guanosine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, moisture-sensitive intermediates to build complex nucleic acid sequences. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acid analogs.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a crucial phosphoramidite precursor for the automated synthesis of DNA and RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of therapeutic ASOs targeting genetic diseases.
• Small Interfering RNA (siRNA) Manufacturing: A key building block for constructing siRNA duplexes used in gene silencing applications.
• Pharmaceutical Intermediate: Acts as a protected intermediate in the multi-step synthesis of novel nucleoside-based antiviral and anticancer agents.
• Research & Development: Essential for academic and industrial R&D focused on nucleic acid chemistry, modification, and probe development.
• Diagnostic Probe Synthesis: Used in the creation of labeled probes for genetic testing and molecular diagnostics.

Basic Information

Product Name	3',5'-o-[Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]-Guanosine
CAS No.	88183-82-8
Molecular Formula	C23H41N5O6Si2
Molecular Weight	547.78 g/mol
Synonyms	Guanosine, 2'-deoxy-2'-(tetraisopropyldisiloxane-1,3-diyl)-; 2'-Deoxy-2'-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)guanosine; 3',5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)guanosine; TIPDS-protected Guanosine; Guanosine 3',5'-bis(TIPDS) ether; N2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine (common protected form); TIPDS-Guanosine; 2'-Deoxyguanosine TIPDS derivative
EINECS	Contact for details

Quality Control

Our 3',5'-o-[Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]-Guanosine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and moisture content to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to prevent degradation due to its hygroscopic nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.