Description

4-((Trimethylsilyl)Ethynyl)Phenol is a versatile organosilicon intermediate featuring both a phenolic hydroxyl group and a protected terminal alkyne. This unique bifunctional structure makes it a valuable building block for advanced organic synthesis, particularly in the construction of complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAC) after deprotection.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators that require phenolic or acetylene-linked structures.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and silicon-containing hybrid materials.
• Liquid Crystal & OLED Materials: A precursor for synthesizing advanced organic electronic materials where the trimethylsilyl-protected alkyne allows for precise molecular assembly.
• Chemical Biology & Bioconjugation: Employed in probe and linker synthesis for labeling biomolecules, leveraging the orthogonal reactivity of the phenol and alkyne groups.
• Organic Synthesis Reagent: A versatile reagent for Sonogashira coupling and other palladium-catalyzed cross-coupling reactions to construct conjugated systems.

Basic Information

Product Name	4-((Trimethylsilyl)Ethynyl)Phenol
CAS No.	88075-18-7
Molecular Formula	C11H16OSi
Molecular Weight	192.33 g/mol
Synonyms	4-(2-Trimethylsilylethynyl)phenol; 4-Hydroxyphenyl(trimethylsilyl)acetylene; p-((Trimethylsilyl)ethynyl)phenol; 4-(Trimethylsilylethynyl)phenol; Phenol, 4-[(trimethylsilyl)ethynyl]-; 4-Ethynylphenol trimethylsilyl ether; TMS-ethynylphenol
EINECS	Contact for details

Quality Control

Our 4-((Trimethylsilyl)Ethynyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.