Description

Phthalic Acid (Ring-D4) is a deuterated isotopologue of phthalic acid, where four hydrogen atoms on the aromatic ring are replaced by deuterium. This stable isotope-labeled compound is essential for advanced analytical and research applications, providing a non-radioactive tracer for precise metabolic and mechanistic studies. It is a critical material for scientists and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries who require high-fidelity internal standards for mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference standard in LC-MS and GC-MS analysis for phthalic acid and related compounds, enhancing accuracy in pharmacokinetic and environmental testing.
• NMR Spectroscopy Solvent & Reagent: Used as a deuterated solvent shift reagent or a tracer in reaction mechanism studies to elucidate molecular pathways without signal interference from protons.
• Pharmaceutical Research & Development: Employed in the synthesis and metabolic studies of deuterated drug candidates, aiding in the development of new chemical entities with improved metabolic profiles.
• Environmental Analysis: Acts as a labeled standard for the detection and quantification of phthalate esters and their metabolites in complex environmental matrices like water and soil.
• Polymer Science Research: Utilized in the study of polymerization mechanisms and the degradation pathways of polyesters and alkyd resins where phthalic acid is a component.
• Biochemical Tracing: Applied in metabolic flux analysis to track the incorporation of aromatic precursors in biological systems.

Basic Information

Product Name	Phthalic Acid (Ring-D4)
CAS No.	87976-26-9
Molecular Formula	C8D4H4O4
Molecular Weight	168.13 g/mol
Synonyms	Benzene-1,2-dicarboxylic Acid (Ring-D4); 1,2-Benzenedicarboxylic Acid-d4; Phthalic Acid-d4; Deuterated Phthalic Acid; [D4]-Phthalic Acid; Isotopic Phthalic Acid; Phthalic-d4 Acid; Benzene-d4-1,2-dicarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of Phthalic Acid (Ring-D4) is produced and analyzed under strict quality management protocols to ensure exceptional isotopic purity and chemical integrity, critical for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % D), chemical purity by HPLC, and specific tests for residual solvents and protonated impurities. Our quality commitment aligns with the stringent requirements of GMP and ISO guidelines for advanced research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept sealed and may require desiccant to maintain stability and prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98% (Ring-D4)
Chemical Purity (HPLC)	≥ 98.0%
Protonated Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.