Description

3,4,5,6-Tetradeuteriopyridin-2-Amine is a deuterium-labeled derivative of 2-aminopyridine, a crucial building block in advanced chemical synthesis. This compound is specifically valued for its role as a stable isotope-labeled internal standard in quantitative mass spectrometry, enabling precise and accurate analytical measurements. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for applications in drug metabolism and pharmacokinetics (DMPK) studies, environmental analysis, and the development of novel deuterated active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the quantitative analysis of 2-aminopyridine and related compounds in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical candidates, leveraging the kinetic isotope effect.
• Synthesis of Deuterated APIs: Acts as a key synthon in the preparation of deuterium-labeled drug molecules, which can offer improved metabolic stability and altered pharmacokinetic profiles.
• Environmental & Food Safety Analysis: Enables accurate quantification of pyridine-based contaminants or residues at trace levels in environmental samples and food products.
• Mechanistic Organic Chemistry Studies: Employed as a probe to study reaction mechanisms and pathways where hydrogen/deuterium exchange is relevant.
• NMR Spectroscopy: Useful as a deuterated starting material for preparing samples for nuclear magnetic resonance (NMR) spectroscopy, simplifying spectral interpretation.

Basic Information

Product Name	3,4,5,6-Tetradeuteriopyridin-2-Amine
CAS No.	87802-54-8
Molecular Formula	C5H2D4N2
Molecular Weight	100.13 g/mol
Synonyms	2-Amino-3,4,5,6-tetradeuteriopyridine; 2-Aminopyridine-d4; Deuterated 2-aminopyridine; 2-Pyridinamine-d4; Perdeuterated 2-aminopyridine; 2-AP-d4; 2-Amino-d4-pyridine; 2-Pyridylamine-d4
EINECS	Contact for details

Quality Control

Our 3,4,5,6-Tetradeuteriopyridin-2-Amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C) and mass spectrometry to confirm isotopic purity (D-enrichment) and chemical identity, as well as HPLC for chemical purity assessment. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity, and residual solvent levels is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere such as nitrogen or argon to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.