Description

1-[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]-2,2,2-Trifluoro-Ethanone o-[(4-Methylphenyl)Sulfonyl]Oxime is a specialized organic intermediate featuring a unique trifluoroethanone oxime core protected by a tert-butyldimethylsilyl (TBDMS) group. This compound is engineered for high-value synthetic applications where precise molecular architecture and functional group stability are critical. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of next-generation pesticides and herbicides, where the oxime and silyl ether functionalities serve as versatile handles for further chemical elaboration.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with tailored properties.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex molecular scaffolds, leveraging its protected hydroxyl group for selective deprotection strategies.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and the behavior of trifluoromethyl groups in various chemical environments.

Basic Information

Product Name	1-[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]-2,2,2-Trifluoro-Ethanone o-[(4-Methylphenyl)Sulfonyl]Oxime
CAS No.	87736-80-9
Molecular Formula	C22H28F3NO4SSi
Molecular Weight	487.61 g/mol
Synonyms	1-[4-[[(tert-Butyldimethylsilyl)oxy]methyl]phenyl]-2,2,2-trifluoroethanone O-[(4-methylphenyl)sulfonyl]oxime; 2,2,2-Trifluoro-1-[4-[[(tert-butyldimethylsilyl)oxy]methyl]phenyl]ethanone O-tosyloxime; TBDMS-protected Trifluoroacetophenone Tosyloxime; (4-((tert-Butyldimethylsilyloxy)methyl)phenyl)(trifluoromethyl)methanone O-tosyl oxime; CAS 87736-80-9; Ethanone, 1-[4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]-2,2,2-trifluoro-, O-[(4-methylphenyl)sulfonyl]oxime
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to ensure structural integrity and purity. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term stability. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.