Description

3-[4-[7-[4-(2,5-Dioxopyrrolidin-3-Yl)Phenoxy]Heptoxy]Phenyl]Pyrrolidin E-2,5-Dione is a high-purity, heterobifunctional crosslinking agent featuring two distinct reactive sites, a maleimide and an NHS ester, separated by a flexible spacer. This compound is essential for creating stable, site-specific conjugations between amine-containing and thiol-containing molecules under mild aqueous conditions. It is a critical intermediate for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the production of targeted therapeutics, diagnostic probes, and functionalized surfaces.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: For site-specific modification of proteins, enzymes, and peptides with fluorophores, biotin, or other functional tags via amine and thiol groups.
• Surface Functionalization: Used to immobilize biomolecules (e.g., proteins, antibodies) onto sensor chips, nanoparticles, or chromatographic supports for biosensing and diagnostic applications.
• Polymer Crosslinking: Acts as a crosslinker in the synthesis of hydrogels and smart polymeric materials with tailored mechanical and responsive properties.
• Diagnostic Reagent Synthesis: Employed in the development of immunoassay components, such as enzyme-antibody conjugates for ELISA and lateral flow tests.
• Biomaterial Engineering: Facilitates the covalent attachment of bioactive ligands to scaffolds for tissue engineering and regenerative medicine.

Basic Information

Item	Details
Product Name	3-[4-[7-[4-(2,5-Dioxopyrrolidin-3-Yl)Phenoxy]Heptoxy]Phenyl]Pyrrolidin E-2,5-Dione
CAS No.	87367-95-1
Molecular Formula	C29H32N2O8
Molecular Weight	536.58 g/mol
Synonyms	BMPS Crosslinker; 3-Maleimidopropionic acid N-hydroxysuccinimide ester (extended chain analog); N-(β-Maleimidopropyloxy)succinimide ester; SMPB (Succinimidyl 4-(p-maleimidophenyl)butyrate) analog; Heterobifunctional crosslinker BMPS; NHS-PEG7-Maleimide (approximate); 1-[7-[4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenoxy]heptyloxy]-4-(2,5-dioxo-3-pyrrolidinyl)benzene; CAS 87367-95-1
EINECS	Contact for details

Quality Control

Every batch of our crosslinking agent is produced and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify chemical identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to ensure it meets the exacting standards required for pharmaceutical R&D and bioconjugation applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) due to its hygroscopic and moisture-sensitive nature. For long-term stability, store under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Functional Assay (Maleimide)	≥ 95.0% of theoretical
Functional Assay (NHS Ester)	≥ 95.0% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.