Description

(2R)-2-[[2-[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-Indol-3-Yl]Acetyl]Amino]-3-Methylsulfanyl-Propanoic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and research interest. This compound is a key chiral synthon in the synthesis of advanced pharmaceutical agents, valued for its specific stereochemistry and functional groups. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the development and production of novel anti-inflammatory medications.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of proprietary NSAIDs and related therapeutic agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target drug molecules.
• Biochemical Research: Used as a tool compound to study cyclooxygenase (COX) enzyme inhibition mechanisms and pathways.

Basic Information

Product Name	(2R)-2-[[2-[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-Indol-3-Yl]Acetyl]Amino]-3-Methylsulfanyl-Propanoic Acid
CAS No.	87270-38-0
Molecular Formula	C23H23ClN2O5S
Molecular Weight	474.96 g/mol
Synonyms	(R)-2-((2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamido)-3-(methylthio)propanoic acid; (2R)-2-[[2-[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]Acetyl]Amino]-3-(Methylsulfanyl)Propanoic Acid; Dexketoprofen Impurity; Dexketoprofen Related Compound; (R)-Dexketoprofen Impurity; NSAID Intermediate; Chiral Indole Derivative; CAS 87270-38-0
EINECS	Contact for details

Quality Control

Our (2R)-2-[[2-[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-Indol-3-Yl]Acetyl]Amino]-3-Methylsulfanyl-Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and comprehensive identification and assay methods, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.