Description

1,1'-(3,6,9,12-Tetraoxatetradecane-1,14-Diyl)Bis(1H-Pyrrole-2,5-Dione) is a specialized bismaleimide derivative featuring a hydrophilic tetraethylene glycol spacer. This compound matters as a high-performance, heterobifunctional crosslinking agent, enabling the precise conjugation of biomolecules under mild aqueous conditions. It is essential for researchers and manufacturers in the life sciences and advanced materials sectors who require reliable, site-specific bioconjugation for developing diagnostics, therapeutics, and functional polymers.

Application

• Bioconjugation Reagent: For site-specific crosslinking of proteins, peptides, and antibodies via thiol-maleimide chemistry, crucial for antibody-drug conjugate (ADC) development and diagnostic assay fabrication.
• Polymer Modification: Acts as a functional monomer or crosslinker for synthesizing and modifying hydrogels, smart polymers, and responsive materials, leveraging its water-soluble PEG spacer.
• Surface Functionalization: Used to create maleimide-activated surfaces on chips, beads, or plates for the immobilization of thiol-containing biomolecules in biosensor and microarray technologies.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of complex drug candidates, particularly where controlled release or targeted delivery is required.
• Material Science Research: Enables the development of novel covalent adaptable networks (CANs) and self-healing materials due to its reversible crosslinking potential.

Basic Information

Product Name	1,1'-(3,6,9,12-Tetraoxatetradecane-1,14-Diyl)Bis(1H-Pyrrole-2,5-Dione)
CAS No.	87135-00-0
Molecular Formula	C20H24N2O8
Molecular Weight	420.42 g/mol
Synonyms	Bis-Maleimide-PEG4; BM(PEG)4; 1,1'-[3,6,9,12-Tetraoxatetradecane-1,14-diyl]bis-1H-pyrrole-2,5-dione; PEG4 Bismaleimide; 1,14-Bis(maleimido)-3,6,9,12-tetraoxatetradecane; BM(PEG)4 Crosslinker; α,ω-Bis-maleimido-poly(ethylene glycol) (n=4); N,N'-Bis[2-(2-maleimidoethoxy)ethyl]glycine amide derivative
EINECS	Contact for details

Quality Control

Our 1,1'-(3,6,9,12-Tetraoxatetradecane-1,14-Diyl)Bis(1H-Pyrrole-2,5-Dione) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. For long-term storage, consider storing desiccated under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content	≤ 1.0%
Solubility	Soluble in DMSO, DMF, Acetonitrile; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.