Description

Sodium Borotritide is a specialized isotopically labeled reagent, specifically the tritiated form of sodium borohydride. This compound is a critical tool for researchers requiring a high-specific-activity reducing agent in tracer studies and metabolic pathway analysis. It is primarily utilized in pharmaceutical R&D, biochemistry, and radiochemistry for labeling and tracking purposes in complex molecular systems.

Application

• Pharmaceutical Research & Development: As a labeled reducing agent in the synthesis of tritium-labeled drug candidates and metabolites for pharmacokinetic and ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Biochemical Tracer Studies: For the selective reduction and isotopic labeling of carbonyl groups (aldehydes, ketones) in biomolecules to trace metabolic pathways and enzyme mechanisms.
• Radiochemistry & Nuclear Medicine: Used in the preparation of tritium-labeled compounds for receptor-binding assays, autoradiography, and other diagnostic research applications.
• Material Science Research: Employed in surface chemistry and catalysis research where a labeled hydride source is needed to study reduction mechanisms and hydrogenation processes.
• Analytical Chemistry: Serves as a standard or reagent in advanced analytical methods requiring isotopic differentiation, such as in mass spectrometry or liquid scintillation counting.

Basic Information

Product Name	Sodium Borotritide
CAS No.	86921-26-8
Molecular Formula	NaBT4
Molecular Weight	~85.84 (for NaBT4)
Synonyms	Sodium Tetrahydridoborate-t4; Sodium Borohydride-t4; Sodium Tetradeuterioborate; Sodium Borodeuteride; NaBT4; Tritiated Sodium Borohydride; Sodium Borohydride (T); Sodium Tetrahydroborate-t4
EINECS	Contact for details

Quality Control

Every batch of Sodium Borotritide is manufactured and handled under strict quality protocols to ensure isotopic purity, chemical purity, and specific activity. Our products undergo rigorous quality testing, including radiochemical purity analysis by HPLC and chemical assay. Certificates of Analysis (COA) detailing specific activity, purity, and solvent composition are provided with each shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures (typically 2-8°C or as specified per batch). Due to its hygroscopic and moisture-sensitive nature, containers should be kept sealed under an inert atmosphere when possible and allowed to reach ambient temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR / NMR)	Conforms
Chemical Purity (HPLC / Titration)	≥ 95%
Radiochemical Purity	≥ 97%
Specific Activity	Customizable (e.g., 10-100 Ci/mmol)
Solvent (if supplied as solution)	Specified (e.g., Diglyme, NaOH solution)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.