Description

Tolgabide CAS NO 86914-11-6 is a synthetic chemical compound belonging to the class of GABAergic agents, specifically a pro-drug of GABA. This compound is of significant interest in pharmaceutical research and development due to its potential anticonvulsant and neuropharmacological properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel central nervous system (CNS) therapeutics and the study of GABA receptor mechanisms.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in preclinical and clinical research for new antiepileptic drugs.
• Neuroscience Studies: Used as a pharmacological tool in academic and industrial laboratories to investigate GABAergic neurotransmission and its modulation.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and method development for HPLC, LC-MS, or other analytical techniques.
• Chemical Synthesis: Acts as a specialized building block for the synthesis of more complex molecules or analogs in medicinal chemistry programs.
• Biochemical Assays: Utilized in in vitro assays to study receptor binding, enzyme inhibition, or other molecular interactions related to its mechanism of action.

Basic Information

Product Name	Tolgabide
CAS No.	86914-11-6
Molecular Formula	C16H14Cl2N2O2
Molecular Weight	337.20 g/mol
Synonyms	4-[[(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide; SL 81.0085; AHR-11797; (E)-4-((4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butyramide; GABA Pro-drug; Tolgabidum
EINECS	Contact for details

Quality Control

Our Tolgabide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.