Description

2-((2-Carboxyphenoxy)Carbonyl)Phenyl-1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindole-3-Acetate is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and pharmaceutical importance. This compound serves as a critical precursor in the synthesis of advanced active pharmaceutical ingredients (APIs), where its precise chemical structure is essential for ensuring final drug efficacy and safety. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent NSAID APIs and related analogs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory agents.
• Process Chemistry: Serves as a standard reference material and a starting material for scale-up and optimization of synthetic routes in pilot plants.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex organic molecules for preclinical and clinical trial material production.

Basic Information

Product Name	2-((2-Carboxyphenoxy)Carbonyl)Phenyl-1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindole-3-Acetate
CAS No.	86811-46-3
Molecular Formula	C33H24ClNO7
Molecular Weight	582.00 g/mol
Synonyms	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[(2-carboxyphenoxy)carbonyl]phenyl ester; Amtolmetin Guacil Impurity; Amtolmetin Guacyl Ester; Amtolmetin Guacyl Impurity; UNII-4R5H97K4Y2; 4R5H97K4Y2; 2-[(2-Carboxyphenoxy)carbonyl]phenyl 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetate
EINECS	Contact for details

Quality Control

Our 2-((2-Carboxyphenoxy)Carbonyl)Phenyl-1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindole-3-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.