Description

(R)-Proxyphylline CAS NO 86540-96-7 is the single enantiomer form of the xanthine derivative proxyphylline, characterized by its specific (R)-configuration at the chiral center. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) where stereochemistry significantly impacts biological activity and safety profiles. It is primarily utilized by advanced pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in developing novel bronchodilators and cardiovascular agents.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiopure theophylline and proxyphylline derivatives.
• Bronchodilator Research: Used in R&D for developing new, more selective asthma and COPD (Chronic Obstructive Pulmonary Disease) medications.
• Cardiovascular Agent Development: Serves as a precursor in studies for potential vasodilatory and heart stimulant compounds.
• Chiral Catalyst & Ligand Synthesis: Employed in the preparation of chiral catalysts or ligands for asymmetric synthesis.
• Metabolite Standard: Acts as a certified reference standard in analytical laboratories for pharmacokinetic and metabolic studies.
• Academic & Clinical Research: Utilized in biochemical and pharmacological studies to investigate the stereospecific effects of xanthine compounds.

Basic Information

Product Name	(R)-Proxyphylline
CAS No.	86540-96-7
Molecular Formula	C₁₀H₁₄N₄O₃
Molecular Weight	238.24 g/mol
Synonyms	(R)-7-(2-Hydroxypropyl)-1,3-dimethylpurine-2,6-dione; (R)-1,3-Dimethyl-7-(2-hydroxypropyl)xanthine; (R)-Proxyphylline; Dexproxiphylline; (R)-Proxiphylline; (R)-Oxypropyltheophylline; (R)-7-(2-Hydroxypropyl)theophylline
EINECS	Contact for details

Quality Control

Our (R)-Proxyphylline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.