Description

(S)-Proxyphylline CAS NO 86540-95-6 is the single enantiomer form of the xanthine derivative proxyphylline, characterized by its specific stereochemistry at the chiral center. This high-purity chiral building block is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers focused on developing novel bronchodilators and cardiovascular agents, where the distinct pharmacological profile of the (S)-enantiomer is essential.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and production of enantiopure bronchodilator and theophylline-related drug candidates.
• Biochemical Research: Used as a standard or reference compound in studies investigating adenosine receptor antagonism and related pharmacological pathways.
• Asymmetric Synthesis: Employed as a starting material or intermediate in sophisticated organic synthesis routes requiring high stereochemical fidelity.
• Analytical Standard: Provides a certified reference material for method development and quality control in analytical laboratories, ensuring accurate chiral purity assessment.

Basic Information

Product Name	(S)-Proxyphylline
CAS No.	86540-95-6
Molecular Formula	C10H14N4O3
Molecular Weight	238.24 g/mol
Synonyms	(S)-7-(2-Hydroxypropyl)-1,3-dimethylpurine-2,6-dione; (S)-1,3-Dimethyl-7-(2-hydroxypropyl)xanthine; (-)-Proxyphylline; L-Proxyphylline; (S)-Proxiphylline; (S)-7-(2-Hydroxypropyl)theophylline; Proxyphylline S-enantiomer
EINECS	Contact for details

Quality Control

Our (S)-Proxyphylline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.