Description

(1R)-1-(2-Thienyl)Ethanol CAS NO 86527-10-8 is a high-purity chiral alcohol derivative of thiophene, serving as a critical chiral building block and resolving agent in advanced organic synthesis. Its value lies in its ability to impart stereochemical control in the production of complex molecules, ensuring high enantiomeric purity in final products. This compound is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, where precise chirality is paramount for biological activity and material properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system.
• Chiral Resolving Agent: Used for the separation of racemic mixtures of acids or other compounds via diastereomeric salt formation.
• Agrochemical Synthesis: Employed in the production of chiral pesticides and herbicides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Material Science Research: Utilized in the development of chiral polymers and liquid crystals with unique optical and electronic properties.
• Flavor & Fragrance Industry: Acts as an intermediate for creating enantiomerically pure aroma chemicals.

Basic Information

Product Name	(1R)-1-(2-Thienyl)Ethanol
CAS No.	86527-10-8
Molecular Formula	C6H8OS
Molecular Weight	128.19 g/mol
Synonyms	(R)-1-(2-Thienyl)ethanol; (R)-1-(Thiophen-2-yl)ethanol; (R)-α-Methyl-2-thiophenemethanol; (1R)-1-(Thien-2-yl)ethanol; (R)-2-Thienylethanol; (+)-1-(2-Thienyl)ethanol; (R)-(-)-1-(2-Thienyl)ethanol; (R)-1-(2-Thienyl)ethyl alcohol
EINECS	Contact for details

Quality Control

Every batch of (1R)-1-(2-Thienyl)Ethanol is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the product meets the high standards required for chiral synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and impurity profiles are available for each lot. Our quality protocols are designed to support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]	-XX° to -XX° (c=1, EtOH)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.