Description

1-Ethynyl-Isoquinoline is a versatile heterocyclic building block characterized by its fused aromatic ring system and terminal alkyne functionality. This compound is of significant value in advanced organic synthesis and materials science due to its ability to participate in click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel molecular architectures and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex bioactive molecules, including potential kinase inhibitors and other therapeutic agents.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its structural motif for enhanced biological activity.
• Material Science: Acts as a monomer or cross-linking agent in the creation of advanced polymers, conductive materials, and metal-organic frameworks (MOFs).
• Chemical Biology & Bioconjugation: The terminal alkyne group enables efficient labeling and conjugation of biomolecules (proteins, nucleic acids) for diagnostic and probe development.
• Catalyst Ligand Synthesis: Utilized to prepare novel nitrogen-containing ligands for transition metal catalysts used in asymmetric synthesis.
• Academic & Industrial R&D: A fundamental research chemical for exploring new synthetic methodologies and reaction pathways in organic chemistry.

Basic Information

Product Name	1-Ethynyl-Isoquinoline
CAS No.	86520-96-9
Molecular Formula	C11H7N
Molecular Weight	153.18 g/mol
Synonyms	1-Ethynylisoquinoline; Isoquinoline, 1-ethynyl-; 1-Isoquinolinylethyne; 1-(Isoquinolin-1-yl)ethyne; 1-Ethynyl-isoquinoline; 86520-96-9 (CAS); 1-Ethynyl-1-isoquinoline
EINECS	Contact for details

Quality Control

Our 1-Ethynyl-Isoquinoline is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor quality specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.