Description

(1S,2S,9S,9Ar)-6-Methyl-7-Amino-9-(Carbamoyloxymethyl)-9A-Methoxy-10-(Benzyloxycarbonyl)-1,2-Epimino-2,3,9,9A-Tetrahydro-1H-Pyrrolo[1,2-A]Indole-5,8-Dione is a complex, high-purity indole alkaloid derivative with a defined stereochemistry, serving as a critical advanced intermediate in modern organic synthesis. Its intricate molecular architecture makes it invaluable for constructing novel pharmacophores and exploring structure-activity relationships. This compound is primarily sought by research institutions and pharmaceutical developers engaged in the discovery of new therapeutic agents, particularly within oncology and neurology.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel, biologically active compounds and potential drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and the development of libraries for high-throughput screening against various biological targets.
• Academic & Institutional R&D: Serves as a reference standard and a starting material for studies in synthetic methodology and natural product analog synthesis.
• Process Chemistry Development: Employed in scaling up synthetic routes for complex molecules during preclinical and early-stage development.
• Bioconjugation & Probe Synthesis: Potential use in creating labeled compounds or probes for biochemical and cellular assays due to its functional groups.

Basic Information

Product Name	(1S,2S,9S,9Ar)-6-Methyl-7-Amino-9-(Carbamoyloxymethyl)-9A-Methoxy-10-(Benzyloxycarbonyl)-1,2-Epimino-2,3,9,9A-Tetrahydro-1H-Pyrrolo[1,2-A]Indole-5,8-Dione
CAS No.	86476-06-4
Molecular Formula	C24H24N4O7
Molecular Weight	480.47 g/mol
Synonyms	Mitomycin C Intermediate Derivative; 10-(Benzyloxycarbonyl)-7-amino-9-(carbamoyloxymethyl)-9a-methoxy-6-methyl-1,2-epimino-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-5,8-dione; (1S,2S,9S,9aR)-9-[(Aminocarbonyl)oxy]methyl]-10-[(benzyloxy)carbonyl]-1,2-epimino-9a-methoxy-6-methyl-2,3,9,9a-tetrahydro-1H-pyrrolo[1,2-a]indole-5,8-dione-7-amine; Mitomycin Analogue; Z-BOC-Mitomycin Derivative
EINECS	Contact for details

Quality Control

Our (1S,2S,9S,9Ar)-6-Methyl-7-Amino-9-(Carbamoyloxymethyl)-9A-Methoxy-10-(Benzyloxycarbonyl)-1,2-Epimino-2,3,9,9A-Tetrahydro-1H-Pyrrolo[1,2-A]Indole-5,8-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) documenting purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below for long-term stability. This compound is light-sensitive and should be handled under inert atmosphere when appropriate to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.