Description

(E)-5-(tert-Butyl-Dimethyl-Silanyloxy)-Pent-2-En-1-Ol CAS NO 86462-75-1 is a high-purity, protected alcohol intermediate featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound is critical for advanced organic synthesis, offering a stable protecting group for alcohols that is compatible with a wide range of reaction conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in the protection of hydroxyl groups on amino acid side chains during solid-phase or solution-phase peptide synthesis.
• Natural Product Synthesis: Serves as a crucial intermediate in the total synthesis of natural products with sensitive alcohol functionalities.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides requiring selective protection/deprotection strategies.
• Material Science Precursor: Acts as a monomer or functionalization agent in the development of specialized polymers and advanced materials.
• Asymmetric Synthesis: Utilized in chiral pool syntheses and the preparation of enantiomerically pure compounds for medicinal chemistry.

Basic Information

Product Name	(E)-5-(tert-Butyl-Dimethyl-Silanyloxy)-Pent-2-En-1-Ol
CAS No.	86462-75-1
Molecular Formula	C11H24O2Si
Molecular Weight	216.40 g/mol
Synonyms	(E)-5-[(tert-Butyldimethylsilyl)oxy]-2-penten-1-ol; 5-[(1,1-Dimethylethyl)dimethylsilyl]oxy-2-penten-1-ol, (E)-; (E)-5-(tert-Butyldimethylsiloxy)pent-2-en-1-ol; (E)-5-(TBDMSO)-2-penten-1-ol; (2E)-5-[(tert-Butyldimethylsilyl)oxy]-2-penten-1-ol; TBDMS Protected Pentenol; (E)-5-[(tert-Butyldimethylsilyl)oxy]-2-penten-1-ol
EINECS	Contact for details

Quality Control

Our (E)-5-(tert-Butyldimethylsilanyloxy)-pent-2-en-1-ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring reliable consistency and traceability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.