Description

tert-Butyldimethylsilylacetylene is a versatile organosilicon reagent featuring a protected terminal alkyne group. This compound is a critical building block in modern synthetic organic chemistry, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications ranging from drug discovery to polymer science.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Sonogashira and other cross-coupling reactions for creating carbon-carbon bonds in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel fungicides, herbicides, and plant growth regulators that require acetylene-derived structures.
• Material Science & Polymer Chemistry: Serves as a monomer or functionalization agent for creating specialty polymers, dendrimers, and conductive materials.
• Natural Product & Fine Chemical Synthesis: Facilitates the introduction of acetylene units into complex molecules like vitamins, flavors, and fragrances.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBS) group protects the acetylene moiety during multi-step syntheses, allowing for selective deprotection later.
• Bioconjugation & Probe Development: Used in click chemistry (e.g., CuAAC reactions) to label biomolecules or create diagnostic probes for research.

Basic Information

Product Name	tert-Butyldimethylsilylacetylene
CAS No.	86318-61-8
Molecular Formula	C8H16Si
Molecular Weight	140.30 g/mol
Synonyms	((tert-Butyldimethylsilyl)ethynyl)trimethylsilane (common error/related compound); TBDMS-acetylene; tert-Butyl(dimethyl)silylacetylene; (tert-Butyldimethylsilyl)ethyne; Ethynyl(tert-butyl)dimethylsilane; 2-(tert-Butyldimethylsilyl)ethyne; TBS-acetylene; Acetylene, (tert-butyldimethylsilyl)-
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilylacetylene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.