Description

(4R,5S)-(+)-cis-4,5-Diphenyl-2-Oxazolidinone is a high-purity chiral auxiliary and building block of significant importance in asymmetric synthesis. Its well-defined stereochemistry makes it a crucial reagent for inducing enantioselectivity in the synthesis of complex organic molecules, particularly active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality chiral intermediates.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Widely used to control stereochemistry in aldol, alkylation, and Diels-Alder reactions.
• Pharmaceutical Intermediate: Key building block for the synthesis of enantiomerically pure drugs and bioactive molecules.
• Catalyst and Ligand Precursor: Serves as a precursor for chiral catalysts and ligands used in metal-catalyzed transformations.
• Agrochemical Synthesis: Employed in the production of chiral pesticides and herbicides with specific biological activity.
• Academic and Industrial R&D: A standard tool in research laboratories for method development and complex molecule construction.
• Process Chemistry Development: Used to establish scalable, stereoselective routes for commercial API manufacturing.

Basic Information

Product Name	(4R,5S)-(+)-cis-4,5-Diphenyl-2-Oxazolidinone
CAS No.	86286-50-2
Molecular Formula	C15H13NO2
Molecular Weight	239.27 g/mol
Synonyms	(4R,5S)-4,5-Diphenyl-2-oxazolidinone; (+)-cis-4,5-Diphenyl-2-oxazolidinone; (4R-cis)-4,5-Diphenyl-2-oxazolidinone; Evans Chiral Auxiliary; (4R,5S)-Diphenyloxazolidin-2-one; (R,S)-cis-4,5-Diphenyl-2-oxazolidinone; NSC 334368
EINECS	Contact for details

Quality Control

Our (4R,5S)-(+)-cis-4,5-Diphenyl-2-Oxazolidinone is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with stringent specifications for use in sensitive asymmetric syntheses. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (ee)	≥99.0%
Melting Point	185 - 190 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.