Description

4-Fluoro-3-(Trifluoromethoxy)Benzyl Bromide is a high-value, multi-functional benzyl bromide derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, imparts significant lipophilicity and metabolic stability to target molecules, making it indispensable for creating novel compounds with enhanced properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) drugs, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Functional Material Development: Employed in creating specialty polymers, coatings, and ligands for catalysis that require specific electronic and steric properties.
• Cross-Coupling Reactions: The benzyl bromide moiety makes it an excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.
• Medicinal Chemistry & SAR Studies: Utilized to introduce the 4-fluoro-3-(trifluoromethoxy)benzyl fragment into lead compounds to study structure-activity relationships (SAR) and optimize drug candidate profiles.

Basic Information

Product Name	4-Fluoro-3-(Trifluoromethoxy)Benzyl Bromide
CAS No.	86256-50-0
Molecular Formula	C8H5BrF4O
Molecular Weight	273.03 g/mol
Synonyms	1-(Bromomethyl)-4-fluoro-3-(trifluoromethoxy)benzene; α-Bromo-4-fluoro-3-(trifluoromethoxy)toluene; (4-Fluoro-3-(trifluoromethoxy)phenyl)methyl bromide; 4-Fluoro-3-trifluoromethoxybenzyl Bromide; 4-Fluoro-α-(bromomethyl)-3-(trifluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Trifluoromethoxy)Benzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, GC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.