Description

4-[tert-Butyl(Dimethyl)Silyl]Oxybut-2-Yn-1-Ol is a specialized organosilicon-protected alkyne alcohol, a key synthetic intermediate in advanced organic chemistry. This compound is valued for its role in introducing protected hydroxyl and alkyne functionalities, enabling complex molecular assembly with high selectivity and yield. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly for introducing alkyne and protected alcohol groups for further coupling reactions (e.g., Click Chemistry).
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its reactive handles allow for the construction of diverse bioactive molecular scaffolds.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, dendrimers, and surface coatings with tailored properties.
• Chemical Biology Probes: Employed in the creation of labeled molecules and probes for studying biological processes due to its bio-orthogonal alkyne group.
• Organic Synthesis: A versatile reagent in academic and industrial laboratories for constructing carbon-carbon bonds and complex natural product analogs via Sonogashira and other cross-coupling reactions.

Basic Information

Product Name	4-[tert-Butyl(Dimethyl)Silyl]Oxybut-2-Yn-1-Ol
CAS No.	86120-46-9
Molecular Formula	C10H20O2Si
Molecular Weight	200.35 g/mol
Synonyms	2-Butyn-1-ol, 4-[(1,1-dimethylethyl)dimethylsilyl]oxy-; 4-[(tert-Butyl)dimethylsilyl]oxy-2-butyn-1-ol; 4-(tert-Butyldimethylsiloxy)but-2-yn-1-ol; 4-(TBDMSO)but-2-yn-1-ol; 4-(tert-Butyldimethylsilyloxy)-2-butyn-1-ol; TBDMS-protected butynol; 4-Hydroxy-2-butynyl tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our production of 4-[tert-Butyl(Dimethyl)Silyl]Oxybut-2-Yn-1-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with internal quality standards and research documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.