Description

Chloro(Diisopropylamino)Methoxyphosphine is a specialized organophosphorus compound widely used as a key reagent in organic synthesis. Its primary value lies in its role as a versatile phosphitylating agent, crucial for constructing complex molecular architectures. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for nucleotide and oligonucleotide synthesis.

Application

• Phosphoramidite Intermediate: A critical building block in the automated solid-phase synthesis of oligonucleotides (DNA/RNA).
• Pharmaceutical Synthesis: Used in the preparation of nucleoside analogs and other active pharmaceutical ingredients (APIs) with phosphate-containing motifs.
• Agrochemical Production: Serves as a precursor in the synthesis of certain pesticides and herbicides that contain phosphonate or phosphoramidate groups.
• Ligand and Catalyst Preparation: Employed in the synthesis of novel phosphorus-based ligands for transition metal catalysis.
• Material Science Research: Used in the development of flame retardants, polymer modifiers, and other functional materials.
• Process Chemistry: Applied in scalable routes for the production of complex molecules requiring selective phosphorylation.

Basic Information

Product Name	Chloro(Diisopropylamino)Methoxyphosphine
CAS No.	86030-43-5
Molecular Formula	C7H17ClNOP
Molecular Weight	197.64 g/mol
Synonyms	Chloro(methoxy)(diisopropylamino)phosphine; Diisopropylamino(chloro)methoxyphosphine; Methoxychloro(diisopropylamino)phosphine; (Diisopropylamino)methoxychlorophosphine; Phosphorochloridous acid, P-(diisopropylamino)-, methyl ester; CDMAP; Chloro-N,N-diisopropyl-methoxyphosphineamine
EINECS	Contact for details

Quality Control

Our Chloro(Diisopropylamino)Methoxyphosphine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.