Description

4,5-Difluoro-2,3-Dihydro-2-Methyl-1H-Indole is a high-purity, fluorinated indole derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular scaffold, which introduces both fluorine atoms and a constrained ring system to modify the physicochemical properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and oncology research, where the fluorinated indole core can enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro substitution pattern can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for functional organic materials, including organic light-emitting diodes (OLEDs) and liquid crystals, due to its electron-deficient aromatic system.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and tags for studying biological processes and enzyme mechanisms.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO laboratories focused on heterocyclic and fluorine chemistry.

Basic Information

Product Name	4,5-Difluoro-2,3-Dihydro-2-Methyl-1H-Indole
CAS No.	85730-59-2
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	2-Methyl-4,5-difluoro-2,3-dihydro-1H-indole; 4,5-Difluoro-2-methylindoline; 2,3-Dihydro-2-methyl-4,5-difluoro-1H-indole; 4,5-Difluoro-2-methyl-2,3-dihydro-1H-indole; 2-Methyl-4,5-difluoroindoline; 85730-59-2; 4,5-Difluoro-2-methylindoline
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2,3-Dihydro-2-Methyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.