Description

T-Butyldichlorosilane is a highly reactive organosilicon compound primarily used as a versatile silylating and protecting agent in organic synthesis. Its value lies in its ability to introduce the bulky tert-butyldimethylsilyl (TBDMS) group, which provides exceptional stability for protecting sensitive functional groups like alcohols and amines under a wide range of reaction conditions. This chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular modification and intermediate synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing the tert-butyldimethylsilyl (TBDMS) protecting group for hydroxyl and amino functions during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the manufacture of silicon-containing pesticides and herbicides, where it acts as a building block for active molecules.
• Polymer & Material Science: Serves as a precursor for modifying polymer surfaces, creating silicone-based materials, and synthesizing specialty silanes for coatings and adhesives.
• Organic Synthesis & Research: A fundamental tool in academic and industrial R&D labs for the protection/deprotection strategy in complex molecule construction, including natural products and fine chemicals.
• Surface Derivatization: Employed to functionalize silica and other inorganic surfaces for chromatography, catalysis, and nanotechnology applications.

Basic Information

Product Name	T-Butyldichlorosilane
CAS No.	85121-42-2
Molecular Formula	C4H10Cl2Si
Molecular Weight	157.11 g/mol
Synonyms	tert-Butyldichlorosilane; (CH3)3CSiHCl2; TBDMS Chloride precursor; tert-Butyldichlorosilyl; Dichloro(tert-butyl)silane; TBDCS; t-Butyldichlorosilane; tert-Butylchlorosilane dichloride
EINECS	Contact for details

Quality Control

Our T-Butyldichlorosilane is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific customer requirements for research or GMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat and incompatible materials. Due to its hygroscopic and highly volatile nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Density (at 20°C)	~1.02 g/mL
Boiling Point	~125-130°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.