Description

3-Ethynyl-1-Methyl-1H-Indole is a versatile heterocyclic building block featuring both an indole core and a reactive ethynyl group. This compound is valued for its role in advanced organic synthesis, particularly in click chemistry and cross-coupling reactions to construct complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or precursor for conductive polymers, organic semiconductors, and advanced polymeric materials.
• Click Chemistry: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition (azide-alkyne click chemistry) for bioconjugation and polymer functionalization.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Chemical Biology: Utilized as a probe or tag in the development of chemical tools for studying biological systems.

Basic Information

Product Name	3-Ethynyl-1-Methyl-1H-Indole
CAS No.	85094-88-8
Molecular Formula	C11H9N
Molecular Weight	155.20 g/mol
Synonyms	1-Methyl-3-ethynylindole; 3-Ethynyl-1-methylindole; 1-Methyl-1H-indole-3-carbaldehyde, ethynyl-; 3-Ethynyl-1-methyl-1H-indole; N-Methyl-3-ethynylindole; 3-Ethynyl-N-methylindole; 1-Methyl-3-ethynyl-1H-indole
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-1-Methyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.