Description

3-Chloro-2-Fluorobenzyl Bromide is a versatile and high-purity halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its precise molecular structure, which enables the introduction of both chloro and fluoro substituents in specific orientations for fine-tuning the properties of target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for constructing complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring specific halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the benzyl bromide moiety acts as a reactive handle for further functionalization.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating halogenated aromatic cores in advanced electronic and display materials.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for creating biaryl structures.
• Ligand & Catalyst Development: Utilized in the preparation of specialized phosphine or nitrogen-based ligands for asymmetric catalysis.
• Chemical Biology Probes: Acts as a starting material for synthesizing molecular probes and tags used in biochemical research.

Basic Information

Product Name	3-Chloro-2-Fluorobenzyl Bromide
CAS No.	85070-47-9
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-(Bromomethyl)-3-chloro-2-fluorobenzene; (3-Chloro-2-fluorophenyl)methyl bromide; 3-Chloro-2-fluoro-α-bromotoluene; 2-Fluoro-3-chlorobenzyl bromide; α-Bromo-3-chloro-2-fluorotoluene; Benzene, 1-(bromomethyl)-3-chloro-2-fluoro-; 85070-47-9
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Fluorobenzyl Bromide is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, GC, and NMR analysis, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.