Description

15(S)-Hete-D8 CAS NO 84807-87-4 is a deuterium-labeled analog of 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), a key eicosanoid signaling molecule derived from arachidonic acid. This stable isotope-labeled compound is essential for precise quantitative analysis and metabolic pathway tracing in biomedical research. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on lipidomics, inflammation, and cardiovascular disease mechanisms.

Application

• Internal Standard for LC-MS/MS Quantification: Serves as a critical reference standard for the accurate measurement of endogenous 15(S)-HETE levels in biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Tracing: Used in stable isotope dilution assays (SIDA) and tracer studies to elucidate the biosynthesis, turnover, and fate of eicosanoids in complex biological systems.
• Biomarker Research and Validation: Enables the development and validation of highly sensitive and specific analytical methods for discovering lipid-based biomarkers related to oxidative stress and inflammatory diseases.
• Drug Discovery & Development: Facilitates pharmacokinetic/pharmacodynamic (PK/PD) studies by allowing researchers to track drug effects on the arachidonic acid cascade and related inflammatory pathways.
• Quality Control in Diagnostic Kits: Employed as a calibrant or control in the manufacturing of in-vitro diagnostic (IVD) kits designed to measure eicosanoid profiles.
• Academic Lipidomics Research: Supports fundamental research into the role of specialized pro-resolving mediators (SPMs) and oxylipins in physiology and pathology.

Basic Information

Product Name	15(S)-Hete-D8
CAS No.	84807-87-4
Molecular Formula	C20H24D8O3
Molecular Weight	328.50 g/mol (approx.)
Synonyms	15(S)-HETE-d8; (15S)-15-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid; 15S-Hydroxyeicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid; 15(S)-HETE-5,6,8,9,11,12,14,15-d8; Deuterated 15(S)-HETE; 15S-HETE-d8; 15(S)-HETE (deuterated)
EINECS	Contact for details

Quality Control

Every batch of 15(S)-Hete-D8 is manufactured and analyzed under strict quality protocols to ensure the highest standards of isotopic purity and chemical identity, which are critical for reliable analytical results. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for isotopic enrichment, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. This product is highly volatile and light-sensitive; allow it to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake and degradation. Keep the container in a well-ventilated, dry place.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (chemical purity)
Isotopic Enrichment (MS)	≥ 98 atom % D
Isomeric Purity (Chiral HPLC)	≥ 98% 15(S)-isomer
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.