Description

4-Chloro-5-Fluoro-1H-Indole-2,3-Dione is a high-purity, halogenated isatin derivative serving as a critical synthetic intermediate in advanced organic chemistry. This compound matters for its role in constructing complex heterocyclic scaffolds, enabling the development of novel active pharmaceutical ingredients and functional materials. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for targeted synthesis and process development.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its halogenated indole core for bioactivity.
• Material Science: Serves as a precursor for organic semiconductors, dyes, and pigments due to its conjugated system.
• Chemical Synthesis: An essential reagent for constructing complex heterocycles like quinolones and fused indole derivatives in academic and industrial R&D.
• Biochemical Probe Development: Utilized in medicinal chemistry to create molecular probes for studying enzyme inhibition and receptor binding.

Basic Information

Product Name	4-Chloro-5-Fluoro-1H-Indole-2,3-Dione
CAS No.	84378-94-9
Molecular Formula	C8H3ClFNO2
Molecular Weight	199.57 g/mol
Synonyms	4-Chloro-5-fluoro-1H-indole-2,3-dione; 4-Chloro-5-fluoroisatin; 5-Fluoro-4-chloroisatin; 4-Chloro-5-fluoro-2,3-dihydro-1H-indole-2,3-dione; Isatin, 4-chloro-5-fluoro-; 84378-94-9; 4-Cl-5-F-isatin
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Fluoro-1H-Indole-2,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.