Description

4H-Imidazo[1,5-A][1,4]Benzodiazepine-3-Carboxylic Acid, 8-Fluoro-5,6-Dihydro-5-Methyl-6-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant synthetic value. This compound matters for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs), particularly within the benzodiazepine analog class. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex heterocyclic molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel benzodiazepine-derived drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to develop new molecules with optimized potency and selectivity.
• API Development: Serves as a key building block in the process development and scale-up of potential Active Pharmaceutical Ingredients (APIs).
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related compounds.
• Biochemical Research: Utilized in studies investigating the interaction of benzodiazepine-like structures with biological targets such as GABA receptors.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) specializing in the custom synthesis of complex, non-commercial organic molecules for client research programs.

Basic Information

Product Name	4H-Imidazo[1,5-A][1,4]Benzodiazepine-3-Carboxylic Acid, 8-Fluoro-5,6-Dihydro-5-Methyl-6-Oxo-
CAS No.	84378-44-9
Molecular Formula	C₁₄H₁₀FN₃O₃
Molecular Weight	287.25 g/mol
Synonyms	8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid; 8-Fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid; Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-; 84378-44-9; 8-Fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4H-Imidazo[1,5-A][1,4]Benzodiazepine-3-Carboxylic Acid, 8-Fluoro-5,6-Dihydro-5-Methyl-6-Oxo- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.