Description

(R)-1-Methyl-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is a chiral, non-natural isoquinoline derivative supplied as a stable hydrochloride salt. This compound is a crucial chiral building block and intermediate in the research and development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targeting drugs. It is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in asymmetric synthesis, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a scaffold or precursor for designing and synthesizing novel bioactive molecules with high enantiomeric purity.
• Asymmetric Catalysis Studies: Serves as a ligand precursor or a model substrate in the development of new chiral catalysts and synthetic methodologies.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes to study biological pathways and receptor interactions.

Basic Information

Product Name	(R)-1-Methyl-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride
CAS No.	84010-67-3
Molecular Formula	C10H14ClN
Molecular Weight	183.68 g/mol
Synonyms	(R)-1-Methyl-1,2,3,4-tetrahydroisoquinoline HCl; (R)-1-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; (R)-1-MTIQ hydrochloride; (R)-N-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; (R)-N-Methyl-TIQ HCl; (R)-1-Methyl-3,4-dihydroisoquinoline hydrochloride; (R)-1-Methyl-3,4-dihydro-2(1H)-isoquinolinone hydrochloride (tautomer); (R)-1-Methyl-1,2,3,4-tetrahydro-isoquinolinium chloride
EINECS	Contact for details

Quality Control

Our (R)-1-Methyl-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC/Chiral HPLC), to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.