Description

(R)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline is a chiral, non-racemic organic compound belonging to the tetrahydroisoquinoline class, serving as a critical building block in asymmetric synthesis. Its value lies in its role as a versatile chiral intermediate and ligand precursor for the development of pharmaceuticals and fine chemicals. This high-purity enantiomer is essential for research and production in pharmaceutical chemistry, agrochemical development, and advanced material science, where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Catalyst Ligand: Used as a precursor for developing chiral ligands in transition metal catalysis, enabling enantioselective transformations.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where specific stereochemistry affects biological activity.
• Fine Chemical Synthesis: Serves as a building block for complex natural products, alkaloids, and other specialty chemicals requiring the (R)-configuration.
• Neurological Research: Used in biochemical studies as a reference compound or precursor for compounds interacting with neurotransmitter systems.
• Material Science: Investigated as a chiral dopant or monomer for advanced polymeric materials with specific optical properties.

Basic Information

Product Name	(R)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	84010-66-2
Molecular Formula	C10H13N
Molecular Weight	147.22 g/mol
Synonyms	(R)-1-Methyl-1,2,3,4-tetrahydroisoquinoline; (R)-1-MTIQ; (R)-1-Methyl-THIQ; (R)-N-Methyl-1,2,3,4-tetrahydroisoquinoline; (R)-N-Methyl-THIQ; (R)-1-Methyl-3,4-dihydroisoquinoline (reduced form); (R)-N-Methyl-1,2,3,4-tetrahydro-isoquinoline; (R)-1-Methyl-1,2,3,4-tetrahydro-isoquinoline
EINECS	Contact for details

Quality Control

Our (R)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality systems to ensure high enantiomeric excess (ee) and chemical purity, suitable for demanding synthetic applications. Each batch is characterized by chiral HPLC, NMR, and GC/MS to confirm identity, purity, and enantiopurity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain purity and enantiomeric integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation [α]	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.