Description

2-Chloro-4-Iodotoluene is a versatile halogenated aromatic compound, specifically a chlorinated and iodinated toluene derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing two distinct, reactive halogen sites that enable selective, sequential functionalization, making it indispensable for constructing complex molecular architectures. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a halogenated phenyl core.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and pesticides where the chloro and iodo groups allow for further derivatization.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis, such as cross-coupling reactions.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: The iodine atom is highly reactive in palladium-catalyzed couplings (e.g., Suzuki, Sonogashira), while the chlorine can be used in subsequent, selective transformations.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and constructing complex, polyfunctionalized aromatic systems in academic and industrial labs.

Basic Information

Product Name	2-Chloro-4-Iodotoluene
CAS No.	83846-48-4
Molecular Formula	C7H6ClI
Molecular Weight	252.48 g/mol
Synonyms	1-Chloro-2-methyl-5-iodobenzene; 2-Chloro-1-methyl-4-iodobenzene; 4-Iodo-2-chlorotoluene; 2-Methyl-5-iodochlorobenzene; Toluene, 2-chloro-4-iodo-; 2-Chloro-4-iodo-1-methylbenzene; 5-Iodo-2-chlorotoluene; 2-Chloro-4-iodotoluene
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Iodotoluene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.