Description

cis-5-Chloro-1,3-Dihydro-1-(3-Hydroxypiperidin-4-Yl)-2H-Benzimidazol-2-One is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting specific biological pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug discovery programs.
• Preclinical Development: Serves as a critical material for producing batches of candidate compounds for pharmacological and toxicological evaluation.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.
• Biochemical Research: Potential use as a tool compound or ligand in biochemical assays and target validation studies.

Basic Information

Product Name	cis-5-Chloro-1,3-Dihydro-1-(3-Hydroxypiperidin-4-Yl)-2H-Benzimidazol-2-One
CAS No.	83706-52-9
Molecular Formula	C₁₂H₁₄ClN₃O₂
Molecular Weight	267.71 g/mol
Synonyms	5-Chloro-1-(3-hydroxy-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one (cis-); cis-5-Chloro-1-(3-hydroxy-4-piperidyl)-1,3-dihydrobenzimidazol-2-one; 83706-52-9; 1-(3-Hydroxy-4-piperidinyl)-5-chloro-1,3-dihydro-2H-benzimidazol-2-one (cis-); cis-1-(3-Hydroxypiperidin-4-yl)-5-chloro-1,3-dihydro-2H-benzimidazol-2-one; 5-Chloro-1-(3-hydroxy-4-piperidinyl)-2-benzimidazolinone (cis-); Benzimidazol-2-one, 5-chloro-1,3-dihydro-1-(3-hydroxy-4-piperidinyl)-, cis-
EINECS	Contact for details

Quality Control

Our cis-5-Chloro-1,3-Dihydro-1-(3-Hydroxypiperidin-4-Yl)-2H-Benzimidazol-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identification by IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this light-sensitive compound.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.