Description

3-[tert-Butyldimethylsilyl]Oxy-1-Propyn-1-Yl]Trimethyl-Silane is a specialized organosilicon reagent featuring dual silyl protecting groups, making it a valuable synthon in advanced organic synthesis. This compound is engineered to provide superior selectivity and stability in sensitive reactions, particularly for the protection of hydroxyl groups on propargylic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the preparation of propargyl alcohol derivatives used in active pharmaceutical ingredient (API) development.
• Nucleoside & Carbohydrate Chemistry: Used for the selective protection of hydroxyl groups in the synthesis of modified nucleosides and complex sugars.
• Natural Product Total Synthesis: Serves as a critical reagent for introducing propargylic ether functionalities in the multi-step synthesis of complex natural products.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent in the development of silicon-containing polymers and specialty resins.
• Agrochemical Research: Employed in the synthesis of novel herbicide and fungicide candidates with propargyl ether motifs.
• Cross-Coupling Reactions: Functions as a substrate in Sonogashira and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.

Basic Information

Item	Detail
Product Name	3-[tert-Butyldimethylsilyl]Oxy-1-Propyn-1-Yl]Trimethyl-Silane
CAS No.	83578-59-0
Molecular Formula	C₁₂H₂₆O Si₂
Molecular Weight	242.51 g/mol
Synonyms	1-[(tert-Butyldimethylsilyl)oxy]-3-(trimethylsilyl)-1-propyne; 3-[(tert-Butyldimethylsilyl)oxy]-1-propyn-1-yltrimethylsilane; Propargyl Alcohol, 1-(tert-Butyldimethylsilyl)-3-(trimethylsilyl) Ether; TBDMS-Propargyl TMS Ether; (3-Trimethylsilyl-2-propynyloxy)-tert-butyldimethylsilane; TMS-Propargyl OTBDMS; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 3-[tert-Butyldimethylsilyl]Oxy-1-Propyn-1-Yl]Trimethyl-Silane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed via GC, NMR, and HPLC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.