Description

4-Maleimidohippuric Acid is a heterobifunctional crosslinking agent that combines a maleimide group with a hippuric acid moiety. This compound is essential for creating stable, site-specific conjugates in bioconjugation chemistry, particularly for linking peptides, proteins, or other biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for developing advanced therapeutic and analytical platforms.

Application

• Bioconjugation Reagent: Used for the covalent coupling of peptides, proteins, and antibodies via the maleimide group's reaction with thiols.
• Drug-Linker Conjugate Synthesis: Serves as a key intermediate in the development of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Diagnostic Probe Development: Facilitates the labeling of biomolecules with reporter groups (e.g., fluorophores, enzymes) for immunoassays and biosensors.
• Surface Functionalization: Employed to modify surfaces (e.g., chips, nanoparticles, beads) with bioactive molecules for research and diagnostic applications.
• Polymer Modification: Acts as a functional monomer or crosslinker for synthesizing or modifying polymers with specific biological activity.
• Stable Conjugate Formation: The hippuric acid moiety can influence solubility and stability, making it valuable for creating conjugates with optimized pharmacokinetic properties.

Basic Information

Product Name	4-Maleimidohippuric Acid
CAS No.	83560-87-6
Molecular Formula	C14H12N2O6
Molecular Weight	304.26 g/mol
Synonyms	N-(4-Maleimidobenzoyl)glycine; Hippuric Acid, 4-Maleimido-; 4-(Maleimidomethyl)hippuric Acid; Maleimidohippuric Acid; 4-Maleimidobenzoylglycine; N-(4-Maleimidobenzoyl)-glycine; 4-Maleimidobenzamidoacetic Acid; p-Maleimidohippuric Acid
EINECS	Contact for details

Quality Control

Our 4-Maleimidohippuric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to moisture and light. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.