Description

Methyl (3S)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indole-3-Carboxylate Hydrochloride is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound, with CAS number 83159-19-7, is valued for its role as a key building block in the synthesis of complex bioactive molecules, particularly those targeting neurological pathways. It is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex drug candidates, particularly in central nervous system (CNS) and neurological disorder research.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the development and scale-up of novel APIs, especially those with indole or tetrahydro-β-carboline core structures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Route Scouting: Employed in the development of efficient, scalable synthetic routes for advanced intermediates under GMP or non-GMP conditions.
• Biochemical Research: May be used as a reference standard or probe in biochemical assays studying enzyme inhibition or receptor binding.
• Fine Chemical Production: A key starting material for the custom synthesis of specialty chemicals and complex organic molecules for various industrial applications.

Basic Information

Product Name	Methyl (3S)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indole-3-Carboxylate Hydrochloride
CAS No.	83159-19-7
Molecular Formula	C14H17ClN2O2
Molecular Weight	280.75 g/mol
Synonyms	(3S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride; Methyl (3S)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylate hydrochloride; (S)-Methyl 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylate HCl; L-Tryptophan methyl ester derivative hydrochloride; Tetrahydro-β-carboline-3-carboxylate methyl ester hydrochloride (S-form); 83159-19-7; (S)-Methyl 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (3S)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indole-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assay, NMR, and MS for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development with custom purity grades and specifications tailored to your project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.