Description

Diazepam-D8 is a stable isotope-labeled analog of the widely used benzodiazepine, diazepam, where eight hydrogen atoms are replaced by deuterium. This compound serves as a critical internal standard in quantitative analytical methods, ensuring unparalleled accuracy and reliability in measurement. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical toxicology sectors who require precise quantification of diazepam and its metabolites.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of diazepam.
• Method development and validation in Pharmaceutical Research & Development for drug metabolism and pharmacokinetic (DMPK) studies.
• Essential reference material in Forensic Analysis and clinical toxicology for the accurate determination of diazepam in biological matrices.
• Calibration standard in Environmental Testing laboratories analyzing for pharmaceutical residues in water systems.
• Used in the synthesis of other deuterium-labeled metabolites for advanced metabolic pathway studies.
• Quality control applications in API (Active Pharmaceutical Ingredient) manufacturing to ensure batch consistency and purity.

Basic Information

Product Name	Diazepam-D8
CAS No.	83056-50-2
Molecular Formula	C16H5D8ClN2O
Molecular Weight	290.78 g/mol
Synonyms	7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one-d8; Deuterated Diazepam; Diazepam (phenyl-d5, methyl-d3); Diazepam-d8; 1,4-Benzodiazepin-2-one, 7-chloro-1-methyl-5-phenyl-, d8-; Diazepam D8; Diazepam (D8)
EINECS	Contact for details

Quality Control

Our Diazepam-D8 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic tests, including NMR for deuterium incorporation and HPLC for chemical purity. We support compliance with GMP and ISO guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.