Description

Alphaxalone-D5 CAS NO 83014-68-0 is a deuterated analog of the neuroactive steroid anesthetic, alphaxalone. This stable isotope-labeled compound is essential for high-precision analytical applications, serving as a critical internal standard for accurate quantification. It is primarily required by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS and GC-MS analysis of alphaxalone in biological matrices (plasma, serum, tissue).
• Quantitative analysis in Pharmacokinetic (PK) and Toxicokinetic (TK) studies.
• Metabolite identification and drug metabolism research (DMPK).
• Bioanalytical method development and validation for regulatory submissions.
• Quality control and reference standard in pharmaceutical manufacturing.
• Neuroscience research investigating neurosteroid pathways and mechanisms.

Basic Information

Product Name	Alphaxalone-D5
CAS No.	83014-68-0
Molecular Formula	C21H27D5O3
Molecular Weight	335.49 g/mol
Synonyms	3α-Hydroxy-5α-pregnane-11,20-dione-d5; Alfaxalone-d5; Alphaxalone-d5; 5α-Pregnan-3α-ol-11,20-dione-d5; 3α-Hydroxy-5α-pregnan-11,20-dione-d5; Deuterated Alphaxalone; [2H5]-Alphaxalone
EINECS	Contact for details

Quality Control

Our Alphaxalone-D5 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity, and analytical results. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.