Description

Adenosine-5',5''-D2 is a stable isotope-labeled analog of adenosine, where two hydrogen atoms are replaced by deuterium at the 5' and 5'' positions of the ribose sugar moiety. This precise labeling makes it an essential internal standard and tracer in quantitative mass spectrometry-based analyses, ensuring high accuracy and reproducibility. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for advanced metabolic studies, drug development, and clinical research applications.

Application

• Quantitative Mass Spectrometry (MS): Serves as a critical internal standard for the accurate quantification of endogenous adenosine and its metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a stable isotope tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of nucleoside-based drug candidates.
• Clinical Diagnostics and Biomarker Research: Enables precise measurement of adenosine pathway metabolites for research into cardiovascular diseases, neurological disorders, and cancer biomarkers.
• Biochemical and Cell Biology Research: Acts as a tool to study purinergic signaling, nucleotide salvage pathways, and energy metabolism in cellular systems without interference from endogenous adenosine.
• Pharmaceutical Reference Standard: Employed in quality control laboratories to develop and validate analytical methods for nucleoside-based active pharmaceutical ingredients (APIs).
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Facilitates structural elucidation and dynamic studies of biomolecules due to the distinct magnetic properties of deuterium.

Basic Information

Product Name	Adenosine-5',5''-D2
CAS No.	82741-17-1
Molecular Formula	C10H11D2N5O4
Molecular Weight	269.26 g/mol
Synonyms	9-β-D-Ribofuranosyladenine-5',5''-d2; Adenosine-d2 (5',5''); [5',5''-²H₂]-Adenosine; Deuterated Adenosine; Adenosine (5',5''-dideutero); Stable Isotope Labeled Adenosine; 6-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl-d2)oxolan-2-yl]purine
EINECS	Contact for details

Quality Control

Our Adenosine-5',5''-D2 is manufactured under strict quality protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We adhere to cGMP principles for the production of reference standards, ensuring traceability, consistency, and reliability for critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.